In 2007, a calcium-silicate-based root canal sealer was developed and launched on the market under the commercial name iRoot SP ® (Innovate Bioceramix, Vancouver, BC, Canada) and was classified as a bioceramic-based root canal sealer. Root canal sealers can be classified according to their composition as zinc-oxide-eugenol-based, calcium-hydroxide-based, resin-based, glass-ionomer-based, silicon-based, and bioceramic-based. Ideally, the root canal sealer should adhere to the root canal walls, promote adequate sealing, have an adequate radiopacity, have low setting contraction, have thin and small particles, not stain the dental tissues, have antimicrobial activity, be biocompatible, be insoluble to tissue fluids, have a workable setting time, and be easily removable from the inside of the root canal system if necessary. The most commonly used materials for filling root canals are gutta-percha associated with a root canal sealer. The filling of the root canal system is an important step in endodontic treatment and has been attributed to the fact that it fosters the sealing of both the main root canal and its accessory ramifications, thus preventing the transit of microorganisms between the root canal and the periradicular tissues. In cell cultures, the chosen method was usually Alizarin Red staining, followed by the evaluation of alkaline phosphatase enzymatic activity and the use of molecular biology tests. Conclusions: According to the methodology used, the most prevalent methods to assess bioactivity in acellular form were the immersion of the material in Hank’s balanced salt solution, followed by surface observation with scanning electron microscopy and energy dispersive X-ray. Meanwhile, for in vivo studies, staining techniques associated with immunohistochemical tests were mainly used to detect mineralization on the material–host tissue interface. In vitro bioactivity was evaluated through the mineralization potential, formation of carbonated apatite on the surface, and the gene expression related to proteins involved in the mineralization process. Results: A total of 53 studies were included in the qualitative synthesis. Eligibility was considered for in vitro and in vivo studies that evaluated the bioactivity potential of bioceramic-based root canal sealers. Two blinded reviewers carried out a comprehensive search in six databases up to January 10th, 2022: MEDLINE, Scopus, Embase, Web of Science, Cochrane Library, and Lilacs/BBO. Methods: The present scoping review is reported in accordance with the PRISMA-ScR Statement and is registered in the Open Science Framework. Hence, the objective of this study was to synthesize and map key concepts related to the bioactivity analysis of bioceramic-based root canal sealers. However, the term bioactivity may be overused and is often misunderstood. The System is moderately priced for the market and has an unsurpassed warranty of two (2) years on equipment and six (6) months on batteries.Introduction: Bioceramic-based root canal sealers are novel materials with a bioactivity potential that stands out compared with conventional root canal sealers. Both System B endodontic units use the same interchangeable batteries allowing the clinician to use them continuously without docking them in a charging cradle. The Pack and Fill units are sold separately. Each Pack unit comes with two (2) rechargeable batteries and a charging unit. The lightweight System B endodontic unit is perfect for single motion down pack and creating post space. The versatile Pack unit features 360° one-touch activation that heats and cools almost instantly for optimal safety, accessibility and control. Each System B endodontic Fill unit comes with two rechargeable batteries, needles and a charging unit. Lightweight and easy to use, the Fill unit's ergonomic handpiece allows for controlled extrusion of either RealSeal™ or traditional gutta percha. Featuring unique features designed for warm vertical and backfill obturation, with System B, endodontic procedures can be performed anywhere without restrictions. Stephen Buchanan, this system brings cordless obturation to new level with its ease of use, compact shape and long-lasting interchangeable batteries. Kerr Endodontics, a global leader in endodontic equipment and material, is proud to introduce the System B™ Endodontic Cordless Obturation System.
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